Paula Abola

Paula Abola

Germany
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About

The loss of my beloved grandmother to Parkinson’s Disease compels me to pursue an area in…

Activity

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Experience

  • State Agency of Medicines of Latvia Graphic

    State Agency of Medicines of Latvia

    Riga, Latvia

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    Remote, Germany

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    Garmisch-Partenkirchen, Bavaria, Germany

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    North Dakota, United States

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    Remote, Germany

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    Remote, Germany

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    Bremen, Germany

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    Latvia

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    Bremen, Germany

Education

  • University of Jamestown Graphic

    University of Jamestown

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    - Introduction to Clinical Research;
    - Biostatistics I and II;
    - Design and Implementation of Clinical Trials;
    - Ethics and Professional Issues in Clinical Research;
    - Epidemiology;
    - Grant Writing for Clinical Research;
    - Critical Evaluation of the Literature;
    - Health Policy and Systems Thinking;
    - Foundations of Leadership;
    - Foundations of Higher Education;
    - Instructional Strategies for the Adult Learner;
    - Instruction Strategies for Online Learning;
    -…

    - Introduction to Clinical Research;
    - Biostatistics I and II;
    - Design and Implementation of Clinical Trials;
    - Ethics and Professional Issues in Clinical Research;
    - Epidemiology;
    - Grant Writing for Clinical Research;
    - Critical Evaluation of the Literature;
    - Health Policy and Systems Thinking;
    - Foundations of Leadership;
    - Foundations of Higher Education;
    - Instructional Strategies for the Adult Learner;
    - Instruction Strategies for Online Learning;
    - Instruction Strategies for Professional Continuing Education;
    - Dissertation

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    - Drug Discovery and Pre-Clinical Research and Development;
    - Toxicology: from Molecules to Man;
    - Clinical Study Design;
    - Practical Aspects of Clinical Research and Early Drug Development;
    - Ethics and Regulation in Clinical Research;
    - Data Management: The Interpretation of Statistics and Pharmacokinetics;
    - Health and Pharmaco-Economics;
    - Pharmaceutical and Healthcare Marketing;
    - Specific Topics in Clinical Trial Design and Elective Project
    - Dissertation:…

    - Drug Discovery and Pre-Clinical Research and Development;
    - Toxicology: from Molecules to Man;
    - Clinical Study Design;
    - Practical Aspects of Clinical Research and Early Drug Development;
    - Ethics and Regulation in Clinical Research;
    - Data Management: The Interpretation of Statistics and Pharmacokinetics;
    - Health and Pharmaco-Economics;
    - Pharmaceutical and Healthcare Marketing;
    - Specific Topics in Clinical Trial Design and Elective Project
    - Dissertation: Efficacy of the traditional oral Monoamine Oxidase-B Inhibitor Rasagiline versus the emerging subcutaneous liquid Levodopa-Carbidopa ND0612 drug in the treatment of Parkinson’s Disease

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    - Inorganic Chemistry and Organic Chemistry;
    - Biochemistry, Cell Biology, and Biotechnology;
    - Medicinal Chemistry and Chemical Biology;
    - Physical Chemistry and Molecular Modelling;
    - Pharmaceutical Chemistry and Analytical Methods;
    - Organometallic Chemistry and Fluorine in Drug Development;
    - Chemical and Pharmaceutical Technology;
    - Scientific Software and Databases and High Throughput Screening;
    - Plant Metabolism and Natural Products;
    - Dissertation: Synthesis…

    - Inorganic Chemistry and Organic Chemistry;
    - Biochemistry, Cell Biology, and Biotechnology;
    - Medicinal Chemistry and Chemical Biology;
    - Physical Chemistry and Molecular Modelling;
    - Pharmaceutical Chemistry and Analytical Methods;
    - Organometallic Chemistry and Fluorine in Drug Development;
    - Chemical and Pharmaceutical Technology;
    - Scientific Software and Databases and High Throughput Screening;
    - Plant Metabolism and Natural Products;
    - Dissertation: Synthesis of a lysine-based bi-functional non-canonical amino acid

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    - Chemistry, Biology, and German B HL;
    - Mathematics, English A, and Economics SL

Licenses & Certifications

Publications

  • Liquid Subcutaneous Levodopa-Carbidopa ND0612 Effects on Motor Symptoms in Individuals with Parkinson’s Disease: A Systematic Review and Meta-Analysis

    Advances in Parkinson’s Disease

    Objective: In the manuscript titled “Liquid subcutaneous Levodopa-Carbidopa ND0612 effects on motor symptoms in individuals with Parkinson’s Disease: A systematic review and meta-analysis”, the objective was to conduct a systematic review with meta-analysis to investigate the effects ND0612 24-hour dosing regimen has on motor symptoms in individuals with Parkinson’s Disease (PD). Introduction: ND0612 is a novel minimally invasive continuous subcutaneous delivery system of liquid…

    Objective: In the manuscript titled “Liquid subcutaneous Levodopa-Carbidopa ND0612 effects on motor symptoms in individuals with Parkinson’s Disease: A systematic review and meta-analysis”, the objective was to conduct a systematic review with meta-analysis to investigate the effects ND0612 24-hour dosing regimen has on motor symptoms in individuals with Parkinson’s Disease (PD). Introduction: ND0612 is a novel minimally invasive continuous subcutaneous delivery system of liquid Levodopa-Carbidopa being investigated for the treatment of PD in individuals experiencing motor symptoms. Methods: A systematic literature search was conducted in PubMed, Cochrane, and EBSCO databases to identify randomized controlled trials investigating the effects of ND0612 on motor symptoms in individuals with PD. Outcomes included the Unified Parkinson’s Disease Rating Scale (UPDRS) Part II and Part III scores. Methodological quality was assessed using the Cochrane Grading of Recommendations Assessment, Development, and Evaluation approach. Meta-analysis was performed using a random effects model with the DerSimonian and Laird method to estimate the effects of the ND0612 24-hour dosing regimen on UPDRS Part II and Part III scores. Results: Three studies were included in our review. There were statistically significant reductions in UPDRS Part II scores (mean difference (MD) −3.299; 95% confidence interval (CI) −3.438, −3.159) and in UPDRS Part III scores (MD −12.695; 95% CI −24.428, −0.962) in the ND0612 24-hour dosing regimen. Results were based on very low certainty of evidence. Conclusion: Based on very low certainty evidence, the ND0612 24-hour dosing regimen is effective at improving motor symptoms in individuals with PD. Our findings suggest that ND0612 is more effective at improving UPDRS Part II and Part III scores in individuals with PD than other pharmacological and non-pharmacological treatments, warranting further study.

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Honors & Awards

  • Scholarship

    Jacobs University Bremen

    Merit-based scholarship granted for Bachelor of Science in Medicinal Chemistry and Chemical Biology at Jacobs University Bremen.

Languages

  • Latvian

    Native or bilingual proficiency

  • English

    Native or bilingual proficiency

  • German

    Full professional proficiency

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